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KMID : 0960920020010020107
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.107 ~ p.112
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Cerebral White Matter Lesions and Hypertension Type: the Ansan Study
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Park Moon-Ho
Park Min-Kyu
Park Kun-Woo
Shin Chol
Lee Dae-Hie
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Abstract
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Background: It is known that white matter lesions (WMLs) may be related to hypertension. The relationship of WMLs to hypertension subtypes, however, remains uncertain, Very few studies have been performed regarding WMLs in Korean people. We investigated the association between the presence and the severity of WMLs with hypertension, its subtypes, and its control status among Koreans.
Methods: A population-based sample of the people aged older than 60 years in Ansan Cohort Study was selected, yielding 108 men and 115 women. Their blood pressure was measured using a highly standardized protocol. Hypertension was defined according to 1999 WHO-ISH guidelines and its subtypes were subclassified. Hypertensives were selected and they were subclassified as hypertensives, isolated systolic hypertensive and isolated diastolic hyperteneives. The subject were further divided into antithypertensive medication and no medication groups. WMLs were rated into 5 subgroups in terms of the presence and the severity by 2 raters using 1.5T MRI scan images. The correlation between WMLs and hypertension subtypes were made.
Results: WMLs were related to hypertension. For hypertension subtypes, systolic blood pressure was more related to WMLs. Among no medication groups with hypertension, isolated systolic hypertensives (odds ratio [OR]=2.66; 95% CI=1.08-6.57; p<0.05) and hypertensives (OR=2.55; CI=1.19-5.46; p<0.05) were related to more extensive WMLs by multiple regression analysis. Among antihypertensive medication groups, uncontrolled hypertension (OR=6.07; CI=2.08-17.78; p<0.01) was significantly related to WMLs compared to normotensives.
Conclusions: Hypertension is a strong independent risk factor of WMLs among Koreans. Regular and tight control of hypertension appears to be of great importance in preventing WMLs in hypertensives.
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KEYWORD
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White matter hyperintensities, Hypertension, Korean
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